significance of myositis - specific and myositis - associated autoantibodies
نویسندگان
چکیده
Autoantibodies to various cellular constituents are detected in the sera of patients with idiopathic inflammatory myopathy (IIM). These autoantibodies are closely associated with characteristic clinical manifestations of the diseases. Therefore, autoantibodies give us much information in clinical diagnosis, classification, prediction of prognosis and choice of treatment in patients with IIM. During the last decade, novel myositis-specific autoantibodies have been identified, such as anti-CADM-140, anti-p155, anti-NXP-2, anti-SAE and anti-200/100, all of which except anti-200/100 are dermatomyositis-specific autoantibodies. The anti-CADM-140 antibody is associated with clinically amyopathic dermatomyositis and acute progressive interstitial pneumonia, anti-p155 is identified in malignancy-associated myositis and anti-200/100 is associated with necrotizing myositis. These new autoantibodies are extremely important because it had been thought that autoantibodies were negative in such subgroups. Target autoantigens have also been identified and their pathogenic roles in IIM have been suggested. Our increased understanding of the autoantigenic properties of these targeted proteins will help us to reveal the pathophysiology of IIM or its complications, and may lead to therapeutic development.
منابع مشابه
Autoantibodies in juvenile-onset myositis: Their diagnostic value and associated clinical phenotype in a large UK cohort
OBJECTIVES Juvenile myositis is a rare and heterogeneous disease. Diagnosis is often difficult but early treatment is important in reducing the risk of associated morbidity and poor outcomes. Myositis specific autoantibodies have been described in both juvenile and adult patients with myositis and can be helpful in dividing patients into clinically homogenous groups. We aimed to explore the uti...
متن کاملMyositis specific autoantibodies: changing insights in pathophysiology and clinical associations.
PURPOSE OF REVIEW Defined autoantibodies are found in about half of the patients with myositis. Traditionally, these autoantibodies have been divided into myositis specific autoantibodies (MSAs) and myositis associated autoantibodies. Several studies have shown that MSAs are associated with specific clinical characteristics and can aid our understanding of the pathophysiology of myositis. REC...
متن کاملAuthor's response to reviews Title: Myositis specific autoantibodies in Korean patients with inflammatory myositis: Anti-140-kDa polypeptide antibody is primarily associated with rapidly progressive interstitial lung disease independent of clinically amyopathic
Title: Myositis specific autoantibodies in Korean patients with inflammatory myositis: Anti-140-kDa polypeptide antibody is primarily associated with rapidly progressive interstitial lung disease independent of clinically amyopathic dermatomyositis.
متن کاملSignificance of Myositis Autoantibody in Patients with Idiopathic Interstitial Lung Disease
PURPOSE Some patients with interstitial lung disease (ILD) related to connective tissue disease (CTD) have a delayed diagnosis of the underlying CTD when the ILD is categorized as idiopathic. In this study, we evaluated the frequency of myositis autoantibodies in patients diagnosed with idiopathic ILD and investigated the clinical significance stemming from the presence of the antibodies. MAT...
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